

🙌 Happy Friday!
Pesticides may keep bugs off our produce, but the long-term cost may be more serious than finding a worm in your apple. 🪱 New research links chlorpyrifos, a common pesticide, to faster aging in fish. 🫣 This week, we’re swimming in that science, and how it may provide clues about pesticides and human aging.
✔ More this week: The simple blood test that could change breast cancer treatment, long live strong legs, and why you should consider an analog bag.
Quick Poll
Do you choose organic produce?
Spotlight


🐟 ‘Safe’ levels of a common pesticide make fish age faster
Fish may be canaries in the coal mine for the dangers of pesticides on aging.

A new study in Science found that low-level exposure to a common pesticide sped up aging in fish. The risk to human lifespan “cannot be ruled out.” ‼
Even at levels considered ‘safe,’ long-term exposure to the pesticide (chlorpyrifos) shortens telomeres, 🧬 the protective caps of DNA. Shorter telomeres are linked to earlier death because they make DNA more vulnerable to damage.
The study: Researchers at the China University of Geosciences analyzed 24,000 fish from three lakes: one clean, one polluted, and one heavily polluted with chlorpyrifos. What they found:
⬇ Shorter lifespan: The most polluted lake had 96% fewer mature fish than the clean lake, meaning most fish died before adulthood.
📈 Faster aging: Fish showed faster and increased aging in liver cells.
⬇ Shorter telomeres: Pollution shortened telomeres, one of the most robust biomarkers of healthy aging, disease, inflammation, and mortality.
❓ Why this matters
Despite being banned in the European Union, chlorpyrifos is commonly used in several US states on citrus fruits, apples, and wheat.
The chemical disrupts the nervous system, increases the production of DNA-damaging toxins, and is linked to shorter telomeres in people.
In previous studies, 33% of lemons have chlorpyrifos residue.
🌎 Big picture: Scientists are calling for more studies on the impact of chlorpyrifos, but in the meantime, different sites like the EWG Dirty Dozen/Clean 15 list can help you identify the safest produce for your health.
The Livelong Women’s Health Summit
What if the only thing standing between you and your healthiest self is just clear information?
Hear leading longevity experts, including Dr. Vonda Wright and Dr. Dean Ornish, teach you what actually protects women’s bodies long-term — and the decisions that matter now — at the Livelong Women’s Health Summit. Use promo code ERIN for a discount on your ticket.
Wellness Watch


🩸 A simple blood test may predict how well someone responds to cancer treatment

A simple new blood test could change how breast cancer is treated. 👱♀ By analyzing cancer DNA in blood, researchers can predict how well a treatment will work, sometimes just weeks after treatment begins, as reported by The Guardian.
“We can avoid giving patients drugs that won’t work and provide them with alternatives before their cancer has a chance to grow,” says first author Dr Iseult Browne, a clinical research fellow at the Institute of Cancer Research, London.
🧪 How it works: The test is a liquid biopsy that allows researchers to flag fragments of tumor DNA (ctDNA) in the blood.
In a study of 167 women with advanced breast cancer, many who showed lower levels of ctDNA at the start of treatment responded better and lived longer. After treatment, low or undetectable levels meant a lower risk of the cancer returning—at least within the year.
⭐ Why this matters
Predictions create possibilities.
Earlier, clearer predictions mean fewer ineffective treatments and making faster pivots to treatments that do work, which boosts the chance of living longer and disease-free.
Beyond breast cancer, researchers are using AI-driven 🤖 tools to predict prostate cancer recurrence, the most common form of cancer diagnosed in men, and even a patient’s risk of cancer metastasis. 🧔♂

In Other News

🦵 The lower body leverage
Leg strength is linked to a better brain.
Are you leveraging your legs? Lower-body strength may be one of the most powerful proxies for brain health 🧠. In a recent study, older adults with the greatest lower-extremity strength had 34% better odds of good cognitive function than those with the weakest legs.
Leg strength protects the brain regardless of age, gender, or the amount of aerobic exercise a person does.
Making gains in strength appears to influence cognitive health more than how often you work out. 🏋
Big picture: Resistance training (bodyweight exercises, weights, or machines) supports memory, attention, and learning because it boosts blood flow to the brain. But focusing on leg strength may provide a unique advantage to the brain, especially for folks who can’t do cardio! 🧓
JOIN The Women’s Livelong Lab (WLL): It’s free to join and easy to use, and we’d love to see you there. 😊 Reach out to [email protected] with any questions.
✨ This week’s highlights
QUICK READS
🕙 The Daily 10: Ten minutes of daily walking is enough to lower the risk of early death by 15%, a new study shows.
🎾 Grand Slam food for healthy aging: Tennis legend Rafael Nadal on the longevity staple for better clarity, immunity, and healthspan.
💉 Shingles vax, slower aging: The shingles vaccine is linked to slower biological aging and less inflammation.
LONG-LEVITY

The Analog (“Stop Scrolling”) Bag
The latest social media trend is (ironically) fighting screen time.

Image credit: Real Simple
Gen Z might be tech-savvy, but they’re leading the fight against digital living through a new trend called the ‘Analog Bag,’ and it’s one that all ages might benefit from. 👜
Coined by content creator Sierra Campbell, the Analog bag is simply a bag with playful, hands-on items to keep you off your phone in public and around friends.
The benefits of participating in hobbies and activities are numerous, fostering greater well-being through improving mindfulness, creativity, emotional regulation, and social opportunities, while boosting problem-solving, motor skills, and cognitive function that support healthy aging. 📖
“My biggest fear is that I’ll lie on my deathbed and regret how much time I spent on my phone,” Campbell says.
The Analog bag might be retro, but it could create a future where you are more present and healthy.
Longevity tote ideas: A newspaper, journal, crossword puzzle, resistance band, massage ball, hand gripper, book, playing cards, or even knitting needles. 📰 🧶

Want to get involved in the Livelong Women’s Health Summit?!
🛍️ Vendors have the opportunity to connect with your audience at the Livelong Women’s Health Summit, April 17–18 in San Francisco. See the media kit for more information.
💫 If you’re passionate about women’s health and longevity and want to help spread the word about the event, you can join us as an Ambassador! Check out the details and reach out to [email protected] with any questions.
Poll response

We asked: Which under-discussed downstream effect of Ozempic interests you most?
Most of you are curious about long-term dependency, which makes sense considering everything people are warning: Once you start, it’s nearly impossible to stop without gaining the weight back. As one person writes, “I’m not thrilled that I have to take this drug for the rest of my life.”

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The information provided about wellness and health is for general informational and educational purposes only. We are not licensed medical professionals, and the content here should not be considered medical advice. Talk to a doctor before trying any of these suggestions.



