New hope for reversing Alzheimer's

🙌 Happy Friday! 

March 13 is National Good Samaritan Day and World Sleep Day 😴 . Quality sleep makes you kinder, so this is a reminder to prioritize rest for yourself and for the good of others. Don’t miss five ways to sleep better.

This week: Reversing Alzheimer’s in mice, cannabis for liver health, multivitamins can slow biological aging, and a UK initiative combining fitness and sustainability.

Quick Poll

Join Livelong April 17-18, 2026, in San Francisco for The Livelong Women’s Health Summit ^™, featuring 75+ speakers on sleep, menopause, metabolic health, bone loss prevention, processed foods, and more.

→ 🛍️ Vendors: This is your chance to connect with intelligent, engaged attendees. See the media kit.

For decades, Alzheimer’s had been seen as a one-way brain decline… that’s probably not as true as we thought.

In a study from Case Western Reserve University, researchers found that restoring NAD+ (nicotinamide adenine dinucleotide) balance in the brain may reverse advanced-stage Alzheimer’s.

What is NAD+? This molecule is present in every cell, helping DNA 🧬 repair and produce cellular energy. As we age, NAD+ levels naturally drop, creating a ‘metabolic crisis’ that can accelerate aging and disease risk—including Alzheimer’s.

This explains why NAD boosters have grown popular among biohackers, researchers, and aging enthusiasts. 👵 Yet the capabilities of this new drug (P7C3-A20) are elevated well beyond NAD+ supplements.

The study: P7C3-A20 is designed to restore NAD+ balance in the brain. When scientists tested it in mice with Alzheimer ’s-like symptoms, they found:

Why this matters: This study challenges key aspects of the Alzheimer’s narrative, shifting the focus toward disease reversal. Although conducted in mice, it opens a promising avenue for therapies targeting other links between metabolism and Alzheimer’s. ✨

Cannabis is not about getting high anymore…in fact, some of the most promising health effects come from the compounds that don’t cause a buzz.

A new study from the Hebrew University of Jerusalem found that two non-psychoactive cannabis compounds, cannabidiol (CBD) and cannabigerol (CBG), may improve liver health by helping the liver process waste and store energy smarter.

Since metabolic liver disease affects nearly one in three US adults ‼— tightly linked to obesity, insulin resistance, and faster aging — the science offers evidence for a new and natural way to support a healthier liver, which in turn may slow the hallmarks of aging.

🐭 The discovery: When mice on an inflammatory high-fat diet were treated with CBD and CBG, the compounds:

Researchers say that these compounds triggered “metabolic remodeling” that helped liver cells store energy more safely and reactivate their internal waste-cleanup systems.

🌏 The big picture: Human studies are needed, but this is evidence that natural plant compounds could help treat metabolic diseases, such as insulin resistance, obesity, and diabetes. 

Multivitamins are the pocketknife of supplements, packed with many essential nutrients linked to healthier aging. Now, a new analysis in Nature Medicine 🌿 suggests that they may also slow biological aging — how quickly your cells age.

Analyzing data from the COcoa Supplement Multivitamins Outcomes Study (COSMOS) study, researchers estimated cellular age using epigenetic clocks ⏱ …tools that measure aging based on DNA markers. 

They found:

⛔ Limits: Epigenetic clocks can predict disease risk and mortality more than calendar age, but they’re not an exact measurement. And vitamin needs vary person to person. 

🗝 Key takeaway: A single daily multivitamin won’t make you immortal, but it may turn back the clock on your cells…if only just a little more.

Hundreds of women have already joined our free Circle community to connect and grow together. Click here to become a member.

Who knew staying active could be this bright?

In cities around the world, people are powering their cities with clean energy by simply walking or running over special pavement tiles.

The concept comes from Pavegen, a UK-based clean energy company that creates floor tiles that convert energy from footsteps into electricity that charges phones, lights soccer fields, and powers local lighting. 🔌

The installation turns a simple walk into a more social and energizing experience, especially when paired with an app that rewards you for more steps, encouraging more movement.

Founder Laurence Kemball-Cook says that people just want community. These tiles are one of the healthiest, easiest ways to help a neighbor out—and get your step count. 😄

💫 If you’re passionate about women’s health and longevity and want to help spread the word about the event, you can join us as an Ambassador! Check out the details and reach out to [email protected] with any questions.

Ask LIV: Our new AI platform can answer your longevity questions based on our database of newsletters, articles, podcasts, and studies. As

Last week, we briefly touched on the contrarian ‘What the H*’ diet for longevity — it’s a relatable counter to modern diet culture, and it’s exactly what it sounds like…just eat whatever you want.

So we asked: When has someone earned the right to say “What the h*, I’ll eat what I want”?

Top three answers:

Funnily, one reader found the philosophical undertone: “I think it depends on what the hell you want to eat 😂”